× ×ª×× × ×ª×¨×פ×
××רש×
| ק×××¦× ×¤×¨×ק×××××ת (ATC4)
|
L01XG
Proteasome inhibitors
|
| ×ר××× ×¤×¢×× (ATC5)
|
Â
|
| צ×רת ×ת×
|
ת××-×ר××× - I.V
|
| צ×רת ××× ××
|
×××§× ×××× ×ª ת×××¡× ××ר×ק×, POWDER FOR SOLUTION FOR INJECTION
××× ×עת ××× ×× ×תר ×× ×רע×× ×ש ××××× ×ת ×תר××¤× ××ת×× ×××× ×× ××××××¥ ××¤× ×©××פ××¢ ××¢××× ×צר××
|
| ×ת××××
|
Kyprolis (carfilzomib) is indicated:⢠in combination with dexamethasone or with lenalidomide plus dexamethasone for the treatment of patients with relapsed or refractory multiple myeloma who have received one to three prior lines of therapy .⢠as a single agent for the treatment of patients with multiple myeloma who have received at least two prior therapies including bortezomib and an immunomodulatory agent and have demonstrated disease progression on or within 60 days of completion of the last therapy. Approval is based on response rate. Clinical benefit, such as improvement in survival or symptoms, has not been verified.
|
| × ×ª×× × ×ס×
|
ת×ר×× ××××× ×ס×
- 12/01/2014
|
×××××ת ×ס×
- תר××¤× ×××××ת ×ר×ש×× ×¢'× ×¨××¤× ××××× ×× ××××× ××רת
|
×ת×××× ×ס×
| ×ת×××× |
ת×ר×× ××××× |
ת××× ×§××× × |
Class Effect |
××¦× ×××× |
×ס×ס ×××××ת
|
| ×§× ××פ×× ×©× × ×ש×××× ×¢× Lenalidomide ×-Dexamethasone ××××× ××¢×× × ×¢× ×× ×××: ×. ××××ª× ×תק××× ×××ר ××פ×× ×§××× ××ש×× ×©××× Thalidomide ×× Bortezomib ××× ××× Lenalidomide. ×. ××××× ××××ר ×ס×××× ××××. ס×××× ×××× ××¢× ××× ×× ××××ר ××××× ××¢×× × ×¢× ××× ××××: â¢×¦××××× ×××§× ×ס×× t(4,14) ×× t (14,16) ×× del 17 p; â¢×××¨× ××××¨× (ת×× ×¤××ת ×-12 ×××ש××) ×©× ××××× ×××ר ×××פ×× ×ר×ש×× ×; â¢×¢××××ת ×××פ×× ×ר×ש×× ×; ××ס×רת ×× ×××× ××××× ×××× ×××פ×× ×תר××¤× ××ת ×××× ××תר×פ×ת ××פ×ר××ת ×××× - Carfilzomib, Elotuzumab, Ixazomib.
|
12/01/2017
|
××× ×§×××××× |
|
××××××× × ×¤×צ×, Multiple myeloma |
|
| ×. ×תר××¤× ×××××¨× ×ª×× ×ª× ×××פ×× ×××××××× × ×¤××¦× ×××תק××× ×× ×××: 1. ×××פ×× ××××× ×©××××ª× ×¢×××× ×× × ×©× ×ת ×××ר ××צ×× ××פ×× ××× ××× ×××× â ××× ×× ×× ××××× ××××ª× ××ר×ת × ×× ×××× ,Thalidomide, Bortezomib, Lenalidomide ××××פ×××× ××××ר××. 2. ××××× ××××ª× ×××× ××××× ×××× ×××פ×× ×תר××¤× ××ת ×××× ××תר×פ×ת ××פ×ר××ת ××××â ×××ת ×××¢× ××××× ×שר ×× ×ש×× ×ª×××× ××× ××××ת ×××ר ,Carfilzomib, Pomalidomide × ×ס××× ××פ××× ×©× 2 ×××××¨× ××פ×× ×××ת ××תר×פ×ת. ×. ××ª× ×תר××¤× ×××××¨× ×××¢×©× ××¤× ××¨×©× ×©× ××××× ×××× ×§×××××× ×× ×¨××¤× ××××× ××××××××××.
|
12/01/2014
|
××× ×§×××××× |
|
××××××× × ×¤×צ×, Multiple myeloma |
|
| ×§× ××פ×× ×©× × ×ש×××× ×¢× Dexamethasone ××××× ×©××××ª× ×תק××× ×××ר ××פ×× ×§××× ××ש×× ×©××× Thalidomide ×× Bortezomib ×× Lenalidomide. ××ס×רת ×× ×××× ××××× ×××× ×××פ×× ×תר××¤× ××ת ×××× ××תר×פ×ת ××פ×ר××ת ×××× - Carfilzomib, Daratumomab, Elotuzumab, Ixazomib.
|
01/03/2021
|
××× ×§×××××× |
|
××××××× × ×¤×צ×, Multiple myeloma |
|
| ×§× ××פ×× ×©× × ×ש×××× ×¢× Lenalidomide ×-Dexamethasone ××××× ×©××××ª× ×תק××× ×××ר ××פ×× ×§××× ××ש×× ×©××× Thalidomide ×× Bortezomib ××× ××× Lenalidomide. ××ס×רת ×× ×××× ××××× ×××× ×××פ×× ×תר××¤× ××ת ×××× ××תר×פ×ת ××פ×ר××ת ×××× - Carfilzomib, Daratumomab, Elotuzumab, Ixazomib.
|
16/01/2019
|
××× ×§×××××× |
|
××××××× × ×¤×צ×, Multiple myeloma |
|
| ××§× ×©×××©× ×××××, ×××× ×תרפ×× ×× ×ש×××× ×¢× Dexamethasone.
|
03/02/2022
|
××× ×§×××××× |
|
××××××× × ×¤×צ×, Multiple myeloma |
|
|
ש×××ש ×ס×
-
|
×ס×רת ××××× ×ס×
- ×. ×תר××¤× ×××××¨× ×ª×× ×ª× ×××פ×× ×××××××× × ×¤××¦× ××קר×× ××××:
- 1. ×§× ××פ×× ×©× × ×ש×××× ×¢× Lenalidomide ×-Dexamethasone ××××× ×©××××ª× ×תק××× ×××ר ××פ×× ×§××× ××ש×× ×©××× Thalidomide ×× Bortezomib ××× ××× Lenalidomide.××ס×רת ×× ×××× ××××× ×××× ×××פ×× ×תר××¤× ××ת ×××× ××תר×פ×ת ××פ×ר××ת ×××× - Carfilzomib, Daratumomab, Elotuzumab, Ixazomib.
- 2. ×××פ×× ××××× ×©××××ª× ×¢×××× ×× × ×©× ×ת ×××ר ××צ×× ××פ×× ××× ××× ××תר×פ×ת ×××× â Thalidomide, Bortezomib, Lenalidomide, ××× ×× ×× ××××× ××××ª× ××ר×ת × ×× ×××ת ××תר×פ×ת ××××ר×ת. ××ס×רת ×× ×××× ××××× ×××× ×××פ×× ×תר××¤× ××ת ×××× ××תר×פ×ת ××פ×ר××ת ×××× - Carfilzomib, Pomalidomide, ×××¢× ××××× ×שר ×× ×ש×× ×ª×××× ××× ××××ת ×××ר × ×ס××× ××פ××× ×©× 2 ×××××¨× ××פ×× ×××ת ××תר×פ×ת ××××ר×ת.
- 3. ××§× ×©×××©× ×××××, ×××× ×תרפ×× ×× ×ש×××× ×¢× Dexamethasone.
- ×. ×תר×פ×ת Carfilzomib, Pomalidomide ×× ××× ×ª× × ×ש×××× ××ת ×¢× ××©× ×××.
- ×. ×××פ×× ×ת×ש×ר ××× ×ª× ××××× ×©××¨× ×××¤× ×-Carfilzomib ××××× ××.
- ×. ××ª× ×תר××¤× ×××××¨× ×××¢×©× ××¤× ××¨×©× ×©× ××××× ×××× ×§×××××× ×× ××××× ××××××××××.
|
|
| ×¢××× ×ר××¤× ××××ר×ת ××¢×××
|
Â
Â
|
ת××× ×ª ×ר×××
ת×ר×× ×¢××××: 14/05/19
AMGEN
ק×פר×××ס - Kyprolis
true
השינוי האחרון נעשה בֹ־23 ביוני 2025 ב־17:06
