× ×ª×× × ×ª×¨×פ×
××רש×
| ××× ×× ×× × ×ספ××
|
|
| ק×××¦× ×¤×¨×ק×××××ת (ATC4)
|
L04AG
Monoclonal antibodies
|
| ×ר××× ×¤×¢×× (ATC5)
|
Â
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| צ×רת ×ת×
|
ת××-×ר××× - I.V
|
| צ×רת ××× ××
|
×××§× ×××× ×ª ת×××¡× ×ר×××ת ××¢×ר××, POWDER FOR CONCENTRATE FOR SOLUTION FOR INFUSION
××× ×עת ××× ×× ×תר ×× ×רע×× ×ש ××××× ×ת ×תר××¤× ××ת×× ×××× ×× ××××××¥ ××¤× ×©××פ××¢ ××¢××× ×צר××
|
| ×ת××××
|
Benlysta is indicated as add-on therapy in patients aged 5 years and older with active, autoantibody-positive systemic lupus erythematosus (SLE) with a high degree of disease activity (e.g., positive anti-dsDNA and low complement) despite standard therapy.Benlysta is indicated in combination with background immunosuppressive therapies for the treatment of adult patients with active lupus nephritis.
|
| × ×ª×× × ×ס×
|
ת×ר×× ××××× ×ס×
- 10/01/2012
|
×××××ת ×ס×
- תר××¤× ×××××ת ×ר×ש×× ×¢'× ×¨××¤× ××××× ×× ××××× ××רת
|
×ת×××× ×ס×
| ×ת×××× |
ת×ר×× ××××× |
ת××× ×§××× × |
Class Effect |
××¦× ×××× |
×ס×ס ×××××ת
|
| ×ת××ת ×××פ×× ×תר××¤× ×××ר×× ×ª×× ×ª× ×××פ×× ×××××× ××¢×× ×× ×¢× ×× ×××: ×. ××××× ××××ת ×××× ×ª×ת ×ער×ת×ת (SLE â Systemic Lupus Erythematosus) פע×××, ××× ××¢×ר××ת ××××ת×ת ×× ××××ת. ×. ×××ר ש×ת×××× ×××פ×× ×ת×ש×ר×× Azathioprine, Hydroxychloroquine, Methotrexate, ×× ××××ª× ×ספקת, ×× ×©××× × ×ס××××× ×ק×× ××פ×× ××××ר. 2. ×¢× ××£ ××××ר ×פסקת ××©× × (1) ××פסק ×××פ×× ×תר××¤× ×××××¨× ×××ר 6 ××××©× ××פ×× ××תק××× ××× ××××: ×. ××¢×ר ש×פ×ר ××ספר ×פרק×× ×¨××ש×× ×× ×¤××××. ×. ×××× ×¢×ר×ת פע×××. ×. ××××× ×ס××××× ×צ××××¤× ××.
|
10/01/2012
|
ר×××××××××× |
|
SLE, Systemic lupus erythematosus, ×××ת |
|
| ×ת××ת ×××פ×× ×תר××¤× ×××ר×× ×ª×× ×ª× ×××פ×× ×××××× ××¢×× ×× ×¢× ×× ×××: ×. ××××× ××××ת ×××× ×ª×ת ×ער×ת×ת (SLE â Systemic Lupus Erythematosus) פע×××, ××× active severe lupus nephritis ×-CNS lupus ×××× ××ª× ×××פ××. ×. ×××ר ש×ת×××× ×××פ×× ×ת×ש×ר×× Azathioprine, Hydroxychloroquine, Methotrexate (××פ×× ××××× ×ס×פרס××× ×××), ×× ××××ª× ×ספקת, ×× ×©××× × ×ס××××× ×ק×× ××פ×× ××××ר.
|
12/01/2014
|
ר×××××××××× |
|
SLE, Systemic lupus erythematosus, ×××ת |
|
| ××××× ×× × 5 ×©× ×× ×××¢×× ×¢× ×××ת ×××× ×ª×ת ×ער×ת×ת (SLE â Systemic Lupus Erythematosus) פע×××, ××× CNS lupus פע×× ×××× ××ª× ×××פ××. ×××פ×× ××× ×ª× ×××ר ש×ת×××× ×××פ×× ×ת×ש×ר×× Azathioprine, Hydroxychloroquine, Methotrexate (××פ×× ××××× ×ס×פרס××× ×××), ×× ××××ª× ×ספקת, ×× ×©××× × ×ס××××× ×ק×× ××פ×× ××××ר. ×××§×¨× ×× ×××פ×× ××× ×ª× ×× ×סף ×××פ×× ×××××× ×ס×פרס××× ×ס×× ×ר××.
|
03/02/2022
|
ר×××××××××× |
|
Systemic lupus nephritis |
|
| ××פ×× ××××ר×× ×¢× ××פ×ס × ×¤×¨×××ס פע×××. ×××פ×× ××× ×ª× ×××ר ש×ת×××× ×××פ×× ×ת×ש×ר×× Azathioprine, Hydroxychloroquine, Methotrexate (××פ×× ××××× ×ס×פרס××× ×××), ×× ××××ª× ×ספקת, ×× ×©××× × ×ס××××× ×ק×× ××פ×× ××××ר. ×××§×¨× ×× × ××ª× ×××× ×תת ×ת ×××פ×× ×× ×סף ×××פ×× ×××××× ×ס×פרס××× ×ס×× ×ר××.
|
03/02/2022
|
ר×××××××××× |
|
Lupus nephritis |
|
| ××פ×× ××××ר×× ×¢× ×××ת ×××× ×ª×ת ×ער×ת×ת (SLE â Systemic Lupus Erythematosus) פע××× ××× CNS lupus פע×× ×××× ××ª× ×××פ××. ×××פ×× ××× ×ª× ×××ר ש×ת×××× ×××פ×× ×ת×ש×ר×× Azathioprine, Hydroxychloroquine, Methotrexate (××פ×× ××××× ×ס×פרס××× ×××), ×× ××××ª× ×ספקת, ×× ×©××× × ×ס××××× ×ק×× ××פ×× ××××ר. ×××§×¨× ×× × ××ª× ×××× ×תת ×ת ×××פ×× ×× ×סף ×××פ×× ×××××× ×ס×פרס××× ×ס×× ×ר××. ×תר××¤× ×× ×ª×× ×ª× ×ש×××× ×¢× Anifrolumab
|
03/02/2022
|
ר×××××××××× |
|
Systemic lupus erythematosus |
|
|
ש×××ש ×ס×
-
|
×ס×רת ××××× ×ס×
- ×תר××¤× ×ª×× ×ª× ×××פ×× ××קר×× ××××:
- ×. ××××ר×× ××¢×× ×× ×¢× ××× ××××:
- 1. ×××ת ×××× ×ª×ת ×ער×ת×ת (SLE â Systemic Lupus Erythematosus) פע××× ××× CNS lupus פע×× ×××× ××ª× ×××פ××.
×××פ×× ××× ×ª× ×××ר ש×ת×××× ×××פ×× ×ת×ש×ר×× Azathioprine, Hydroxychloroquine, Methotrexate (××פ×× ××××× ×ס×פרס××× ×××), ×× ××××ª× ×ספקת, ×× ×©××× × ×ס××××× ×ק×× ××פ×× ××××ר. ×××§×¨× ×× × ××ª× ×××× ×תת ×ת ×××פ×× ×× ×סף ×××פ×× ×××××× ×ס×פרס××× ×ס×× ×ר××.
×תר××¤× ×× ×ª×× ×ª× ×ש×××× ×¢× Anifrolumab.
- 2. ××פ×ס × ×¤×¨×××ס פע×××.
×××פ×× ××× ×ª× ×××ר ש×ת×××× ×××פ×× ×ת×ש×ר×× Azathioprine, Hydroxychloroquine, Methotrexate (××פ×× ××××× ×ס×פרס××× ×××), ×× ××××ª× ×ספקת, ×× ×©××× × ×ס××××× ×ק×× ××פ×× ××××ר. ×××§×¨× ×× × ××ª× ×××× ×תת ×ת ×××פ×× ×× ×סף ×××פ×× ×××××× ×ס×פרס××× ×ס×× ×ר××.
- ×. ×××××× ×× × 5 ×©× ×× ×××¢×× ×¢× ×××ת ×××× ×ª×ת ×ער×ת×ת (SLE â Systemic Lupus Erythematosus) פע×××, ××× CNS lupus פע×× ×××× ××ª× ×××פ××.
×××פ×× ××× ×ª× ×××ר ש×ת×××× ×××פ×× ×ת×ש×ר×× Azathioprine, Hydroxychloroquine, Methotrexate (××פ×× ××××× ×ס×פרס××× ×××), ×× ××××ª× ×ספקת, ×× ×©××× × ×ס××××× ×ק×× ××פ×× ××××ר. ×××§×¨× ×× ×××פ×× ××× ×ª× ×× ×סף ×××פ×× ×××××× ×ס×פרס××× ×ס×× ×ר××.
|
|
| ×ת××ת ××× ××
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Posology and method of administration
|
| ×ת××××ת × ××
|
Contraindications
|
| ת×פע×ת ×××××
|
Undesirable effects
|
| ת××××ת ××× ×ª×¨×פת××ת
|
Interaction with other medicinal products and other forms of interaction
|
| ש×××ש ×××ר××× ××× ×§×
|
Pregnancy and Lactation
|
| פר×ק×××× ××ק×
|
Pharmacodynamic Properties
|
| פר×ק×ק×× ××ק×
|
Pharmacokinetic Properties
|
| ×¢××× ×ר××¤× ××××ר×ת ××¢×××
|
Â
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| ××פ×ש ×××ר××
|
×××ר×× ×-PubMed
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| ××××¢ ×רשת
|
RxList WebMD Drugs.com
|
| ×©× ×צר×
|
GLAXO GROUP LTD, UK
|
| ×©× ××¢× ×ר×ש××
|
GLAXO SMITH KLINE (ISRAEL) LTD
|
| ר×ש×××
|
ת×ר×× ××ש×: 06/2011. ר×ש××× ×ת×ר××: 01/2017
|
| ת×ר×× ×¢×××× ××ר××
|
03/12/2023
|
ת××× ×ª ×ר×××
ת×ר×× ×¢××××: 03/12/2023
GLAXO
×× ××ס×× - Benlysta
true
השינוי האחרון נעשה בֹ־19 בספטמבר 2024 ב־22:46
