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| ×§×××¦× ×¤×¨××§×××××ת (ATC4)
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L01EC B-Raf serine-threonine kinase (BRAF) inhibitors
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| ×ר××× ×¤×¢×× (ATC5)
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פ××× - PER OS
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קפס×××ת ×'×××× ×§×©×××ת, HARD GELATIN CAPSULES ××× ×עת ××× ×× ×תר ×× ×רע×× ×ש ××××× ×ת ×תר××¤× ××ת×× ×××× ×× ××××××¥ ××¤× ×©××פ××¢ ××¢××× ×צר××
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| ×ת××××
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BRAF V600E or V600K Mutation-Positive Unresectable or Metastatic MelanomaEncorafenib is a kinase inhibitor indicated, in combination with binimetinib, for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation.BRAF V600E Mutation-Positive Metastatic Colorectal Cancer (CRC)Encorafenib is indicated in combination with cetuximab, for the treatment of adult patients with metastatic colorectal cancer (CRC) with a BRAF V600E mutation, as detected by an approved test after prior therapy.BRAF V600E Mutation-Positive metastatic non-small cell lung cancer (NSCLC)Encorafenib is a kinase inhibitor indicated, in combination with binimetinib, for the treatment of adult patients with metastatic non-small cell lung cancer (NSCLC) adenocarcinoma with a BRAF V600E mutation, as detected by an approved test.
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| × ×ª×× × ×ס×
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ת×ר×× ××××× ×ס×
- 16/01/2019
|
×××××ת ×ס×
- תר××¤× ×××××ת ×ר×ש×× ×¢'× ×¨××¤× ××××× ×× ××××× ××רת
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×ת×××× ×ס×
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ת×ר×× ××××× |
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Class Effect |
××¦× ×××× |
×ס×ס ×××××ת
|
| ×. ×תר××¤× ×ª×× ×ª× ×ש×××× ×¢× Binimetinib ×××פ×× ×××× ××× ×תק××ת (×ר×רת×ת ×× ×©××× × × × ×ª×××) ××××× ××××× ×××צ×× ×-BRAF. ×. ××××× ××××ª× ×××× ××××× ×××× ×××פ×× ×תר××¤× ××ת ×××× ××תר×פ×ת ××פ×ר××ת ×××× â Encorafenib, Dabrafenib, Vemurafenib ××¢× ××× ×× ××× ××× ×ש×× ×תק×× (×× × ×ª×× ×× ×ר×רת×) ×× ×ª×××ר ××××ª× ×××× ××× ××× ××× ×ש×× ×ר ××¡×¨× ×× ×ת××. ×. ××ª× ×תר××¤× ×××××¨× ×××¢×©× ××¤× ××¨×©× ×©× ××××× ×××× ×§××××××.
|
16/01/2019 |
××× ×§×××××× |
|
××× ××× ×תק××ת (×ר×רת×ת ×× ×©××× × × × ×ª×××) BRAF+ |
|
| ×ש×××× ×¢× Cetuximab ×××פ×× ×סר×× ××¢× ×ס ×× ×¨×§××× ×ש×× ×ר×רת×, ××××× ××××× ×××צ×× ×ס×× BRAF V600E, ×שר ×§××× ××פ×× ×§××× ××××ת×.
|
19/02/2025 |
××× ×§×××××× |
|
סר×× ××¢× ×ס, סר×× ×¨×§×××, colorectal cancer, CRC |
|
|
ש×××ש ×ס×
-
|
×ס×רת ××××× ×ס×
- ×תר××¤× ×ª×× ×ª× ×××פ×× ××קר×× ×××××:
- ×ש×××× ×¢× Binimetinib ×××פ×× ×××× ××× ×תק××ת (×ר×רת×ת ×× ×©××× × × × ×ª×××) ××××× ××××× ×××צ×× ×-BRAF.
××××× ××××ª× ×××× ××××× ×××× ×××פ×× ×תר××¤× ××ת ×××× ××תר×פ×ת ××פ×ר××ת ××××: Encorafenib, Dabrafenib, Vemurafenib. ××¢× ××× ××, ××× ××× ×ש×× ×תק×× (×× × ×ª×× ×× ×ר×רת×) ×× ×ª×××ר ××××ª× ×××× ××× ××× ××× ×ש×× ×ר ××¡×¨× ×× ×ת××
- ×ש×××× ×¢× Cetuximab ×××פ×× ×סר×× ××¢× ×ס ×× ×¨×§××× ×ש×× ×ר×רת×, ××××× ××××× ×××צ×× ×ס×× BRAF V600E, ×שר ×§××× ××פ×× ×§××× ××××ת×
- ××ª× ×תר××¤× ×××××¨× ×××¢×©× ××¤× ××¨×©× ×©× ××××× ×××× ×§××××××.
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Contraindications
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Interaction with other medicinal products and other forms of interaction
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| ש×××ש ×××ר××× ××× ×§×
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Pregnancy and Lactation
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| פר××§×××× ×××§×
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Pharmacodynamic Properties
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Pharmacokinetic Properties
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| ××פ×ש ×××ר××
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×××ר×× ×-PubMed
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RxList WebMD Drugs.com
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| ×©× ×צר×
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ARRAY BIOPHARMA INC, USA
|
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MEDISON PHARMA LTD
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ת×ר×× ××ש×: 7/2018. ר×ש××× ×ת×ר××:
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07/07/2025
|
ת×ר×× ×¢××××: 07/07/2025
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השינוי האחרון נעשה בֹ־7 ביולי 2025 ב־04:47